Starting a run with the Ghost Deck gives you the Hex card which adds Polychrome (X1.5 Mult) to one random joker at the cost of destroying all others. To avoid accidentally destroying a valuable joker (especially in the early game when money is always a major constraint) its best to use the Hex card as soon as a good joker is found. This joker should preferably be a joker which you are likely to keep into late into the game such as a scaling joker like Spare Trousers or a powerful joker such as Stuntman As such the first joker obtained is of high importance and it is worth considering restarting a run if no good candidates appear in the first couple of shops.

Alternatively the Hex card may be sold for $2 providing a small cash infuse. Although significantly lower than the Yellow Decks $10 bonus this may allow the player to purchase an early spectral card. If this option is taken deck-modifying spectral cards should be prioritized. Ouija and Grim in particular can be seen as more valuable than the starting Hex as Polychromes x1.5 Mult loses some of its significance after the mid-game while these cards can set the player up for consistent Four/Five of a Kind hands in the late game.

This deck is unique in that it can purchase the Deja Vu card from the shop which grants a red seal to a chosen card. Unlike seeing it in Spectral packs having the Deja Vu in the consumable slot means that it can be saved to go onto any card in your deck. This can make certain strategies far more reliable. Most notably getting a Red Seal King with the Baron joker is far FAR easier on the Ghost deck than with any other deck. You can then use the Aura card to make this Red Seal card even stronger then get a Purple Seal and put it on a card of the same rank and then use the Cryptid card can then make 2 copies of the Red/Purple Seal card allowing the entire deck to be built around this one card. This strategy makes the Ghost deck one of the most reliable decks for getting far in Endless mode.

Chaos the Clown gives 1 free reroll increasing the likelihood of encountering spectral cards.